Premature Birth is an Unsolved Problem of the 21st Century
Keywords:
atosiban, oxytocin receptor blocker, preterm birthAbstract
The problem of preterm birth is one of the urgent medical and social problems in obstetrics. Despite significant progress in the development of new tocolytic drugs, the incidence of preterm birth does not show a clear downward trend. The article presents the results of scientific research on the inhibition of spontaneous contractile activity of the uterus during preterm birth, which increases the chances of survival of the newborn.
Atosiban is the first drug specifically designed to suppress labor. Comparing it with other drugs with a tocolytic effect, it was shown that in terms of efficacy, safety and tolerability, atosiban is not inferior, but superior to them in the treatment of pregnant women with threatened preterm birth.
References
Veropotvelyan P.N., Narytnik T.T., Veropotvelyan N.P. Features of the course of pregnancy and early preterm labor at 22–27 weeks //Medical aspects of women's health. - 2013. - No. 7.
Veropotvelyan N.P., Veropotvelyan P.N., Volenko N.V., Walk Yu.S. A modern view on placental dysfunction in patients suffering from premature termination of pregnancy // Women's Health, 2012, No. 1 (67). – P. 68–74.
DobrokhotovaYu.E., Jobava E.M., Stepanyan A.V., SudakovaG.Yu. Micronized progesterone in the treatment of threatened preterm birth: a systematic review and meta-analysis of randomized and controlled trials. // Issues of gynecology, obstetrics and perinatology. - 2019. - V. 9, No. 4. - S. 63-70.
Kozlov P.V. Etiology and pathogenesis of premature rupture of membranes in preterm pregnancy. // Issues of gynecology, obstetrics and perinatology . - 2017. - Volume 6, No. 2. - S. 64-72. Sarkisova L. V. Morphological features of the placenta in preterm birth // Problems of biology and medicine. - 2012. - T. 1. - S. 166.
Sarkisova L.V. Features of the clinical course of preterm labor and perinatal outcomes// Collection of materials of the first Bukhara international conference of medical students and youth.2019. -S. 262-263.
Sarkisova L. V. Analysis of the risk of preterm birth by assessingpolymorphism of tumor necrosis factor alpha and interleukin 1-beta //Biology and Integrative Medicine. – 2021. – no. 2 (49). - S. 104-117.
Sarkisova L. V. et al. Modern aspects of the treatment of pregnant women with gestosis , based on changes in central hemodynamics // Russian Bulletin of the obstetrician-gynecologist. - 2003. - no. 4. - P. 56.
Sarkisova L. V. et al. Modern aspects of the treatment of pregnant women with preeclampsia, based on changes in central hemodynamic parameters // Russian Bulletin of the Obstetrician-Gynecologist. - 2003. - no. 4. - S. 56.
Fedotovskaya , O.I. Modern approaches and prospects for determining the risk of preterm birth / O.I. Fedotovskaya , Z.S. Khodzhaeva, A.E. Donnikov // VI International Congress on Reproductive Medicine: materials of the Congress. - Moscow, 2016. - S. 324
Khodjaeva, Z.S. Drug therapy of threatening preterm labor (literature review) / Z.S. Khodzhaeva, O.I. Fedotovskaya , AM Kholin // Obstetrics and Gynecology. - 2016. - No. 5. - S. 17-22.
Arthur P., Taggart MJ, Mitchell BF Oxytocin and parturition: a role for increased myometrial calcium and calcium sensitization, Front. biosci . 20 17 12:619–33.
Akerlund M., CarlssonAM, Melin P., Trojnar J. The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin. Actaobstet .Gynecol . Scand.2020 64: 499–504.
Baev OR, Kozlova OA, Tysyachnyi OV, Usova EA The use of oxytocin receptors blocking agent atosiban to suppress spontaneous labor. Am. J. Obstet. Gynecol. 2015 1:5–117
Baskett TF The development of oxytocic drugs in the management of postpartum haemorrhage . Ulster Med. J. 201 4 Suppl .: 2–6.
Du Vigneaud V., Ressler C., Trippett S. The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin. J Biol. Chem. 1953 205: 949–57
Finnstrom O., Olaussen P.O. , Sedin G., Serenius F., Svenningsen N., Thiringer K. Et al. The Swedish national perspectives study on extremely low birthweight (ELBW) infants. Incidence, mortality, morbidity and survival in relation to level of care. Actapaediatr . 1999 86: 503–11.
Fuchs AR, Husslein P., Fuchs F. Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin. Am. J. Obstet. Gynecol. 2000 141(6): 694–7.
Greig PC, Massmann GA, Demarest KT, Weglein RC, Holland ML, Figueroa JP Maternal and fetal cardiovascular effects and placental transfer of the oxytocin antagonist atosiban in late gestation pregnant sheep. Am. J. Obstet .Gynecol2020. 169(4): 897–902.
Goodwin TM, Valenzuela G., Silver H., Hayashi R., Creasy GW, Lane R. Treatment of preterm labor with the oxytocin antagonist atosiban . Am. J. Perinatol .2016 13 (3): 143–6.
Helmer H., Brunbauer M., Rohrmeister K. exploring the role of Tractocile in everyday clinical practice. Br. J.
Lamont RF, Kam KYR Atosiban as a tocolytics for the treatment of spontaneous preterm labor. Expert Rev. Obstet. Gynecol. 20 18 3(2): 163–74.
Lawn JE, Gravett MG, Nunes TM, Rubens CE, Stanton C. GAPPS Review Group. Global report on preterm birth and stillbirth (1 of 7): definitions, description of the burden and opportunities to improve data. BMC Pregnancy Childbirth. 2010 10 (Suppl. 1): S1–22. Available at: http://www.biomedcentral.com/1471 2393/10/S1/S1
Nour NM Premature delivery and the millennium development goal. Rev. obstet. Gynecol. 2012 5 (2): 100–5.
Nanetti L., Raffaelli F., Giulietti A., Sforza G., RaffaeleGiannubilo S., Ciavattini A. et al. Oxytocin, its antagonistatosiban , and preterm labor: a role for placental nitric oxide. J. Matern . Fetal Neonatal Med. 2014 Jul 11:1–6.
Obstet. Gynaecol . 2003 110 (Suppl. 20): 113–5.
Romero R., Sibai BM, Sanchez Ramos L., Valenzuela GJ, Veille JC, Tabor B. et al. An oxytocin receptor antagonist ( atosiban ) in the treatment of preterm labor: A randomized, doubleblind , placebocontrolled trial with tocolytic rescue. Am . J. Obstet. Gynecol. 2000 182: 1173–83.
Sanu O., Lamont RF Critical appraisal and clinical utility of atosiban in the management of preterm labor. Ther .Clinic .riskManag . 2010 6:191–9.
Serov VN, Salov IA, Burlev VA, Marinushkin DN The role of fetal oxy tocin induction of uterine activity. Russian Gazette obstetriciangynecolo gist. 2001 1 :15–8.
Sarkisova LV, Morphological features of placentas in preterm labor //Problems of biology and medicine. - 2012. - Vol. 1. - P. 166.LITERATURE FOR CITATION
Sarkisova LV, Mukhtorovna KG, Kobylovna ES Premature Birth In A Modern Aspect //International Journal of Bio-Science and Bio-Technology. - 2019. - Vol. 11. - No. 10. - pp. 31-37
Usta IM, Khalil A., Nassar AH Oxytocin antagonists for the management of preterm birth: a review. Am.J. _ Perinatol . 2011 28 (6): 449–60. Doi : 10.1055/s00301270111.
Vrachnis N., Malamas FM, Sifakis S., Deligeoroglou E., Iliodromiti Z. The oxytocinoxytocin receptor system and its antagonists as tocolytic agents. Int. J. Endocrinol . 2011 2011: Article ID 350546. Doi:10.1155/2011/350546
Valenzuela GJ, Craig J., Bernhardt MD, Holland MI Placental passage of the oxytocin antagonist atosiban . Am. J. Obstet. Gynecol. 1995 172 (4, Pt 1): 1304–6.
Wood N., Marlow N., Costeloe K., Chir B., Gibson A., Wilkinson A. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N. Engl. J. Med. 2000 343: 378–84.
Woodcock N., Taylor C., Thornton S. Effect of oxytocin receptor antagonist and rho kinase inhibitor on the Ca ++ sensitivity of human myometrium. Am. J. Obstet. Gynecol. 20 14 190: 222–8.
Shamsievna R. G. Modern Aspects of Studying the Features of Morphofunctional Characteristics of Testes under Various Factor Influences //Eurasian Scientific Herald. – 2022. – Т. 7. – С. 279-286.
Sh R. G. Experimental modelling of traumatic brain injury in white rats //Тиббиётда янги кун. – 2021. – Т. 2. – №. 34. – С. 197-200.
